Physiologic Requirements for Auxiliary Liver Homotransplantation.

Experimental and clinical observations after homotransplantation of the whole liver.

In this report, attention will be focused upon new or contraversial aspects of homotransplantation of the liver. Although interest in liver transplantation dates from Welch's first reports almost 10 years ago (1, 2), there was at first little justification from laboratory experimentation for hope that such a procedure had a therapeutic clinical potential. In the recent past, the outlook has mar...

Homotransplantation of the Liver1

The feasibility of hepatic homotransplantation has been clearly established in principle inasmuch as several animals are still alive almost 3 years after complete hepatectomy and liver replacement. Both orthotopic and auxiliary operations are complicated surgical techniques. Nevertheless, the results in dogs are comparable to those which can be obtained with homotransplantation of the kidney. I...

Platelet changes following clinical and experimental hepatic homotransplantation.

DURING the last four years, ten patients with liver disease have been treated at the University of Colorado with either orthotopic or auxiliary hepatic homotransplantation.1~2 A hemorrhagic diathesis, explained at least partially by increased circulating fibrinolysins;? frequently complicated the operative procedure. Derangements in other clotting factors are also known to occur,:3.4 but the pr...

Homotransplantation of the liver.

Human C'3: evidence for the liver as the primary site of synthesis.

The liver is the primary, if not sole, site of synthesis of the third component of human complement, as shown by a change in the recipient from C'3 FS(0.6) to C'3 SS, the donor type, following homotransplantation of the liver.